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氨茶硷治疗哮喘已有多年。Mitenko等在茶硷药物动力学基础上,提出以患者体重来计算氨茶硷剂量:负荷量5.6毫克/公斤,维持量0.9毫克/公斤/小时。据报告这个剂量使95％患者血浆茶硷浓度保持在5～15毫克/升。本文作者为了检验这个剂量是否合理,对50例正在发病的哮喘住院患者,按以上剂量使用氨茶硷,并测定用药后血浆茶硷浓度。 50例中男20例,女30例,年龄15～70岁,有15例接受了氨茶硷负荷量,以20分钟静脉缓注。为了不使付作用增加。24小时维持量不超过1,500毫克,静脉输注给药。21例接受了1,500毫克/24小时的最大剂量。
Ammonia has been used to treat asthma for many years. On the basis of theophylline pharmacokinetics, Mitenko et al. Proposed to calculate the dose of aminophylline based on the patient’s body weight: 5.6 mg / kg load and 0.9 mg / kg / hr maintenance dose. This dose is reported to maintain plasma theophylline concentrations in 5 to 15 mg / l in 95% of patients. In order to test the reasonableness of this dose, the authors of this study used aminophylline in 50 inpatients with developing asthma at the above doses and determined the plasma theophylline concentration after treatment. 50 cases of 20 males and 30 females, aged 15 to 70 years old, 15 patients received ammonia load, intravenous infusion of 20 minutes. In order not to increase the role of pay. 24-hour maintenance does not exceed 1,500 mg, intravenous infusion administration. Twenty-one patients received the maximum dose of 1,500 mg / 24 hours.