论文部分内容阅读
本文对58例膀胱肿瘤石蜡包埋标本进行了形态定量分析检测。结果表明,核平均面积,核平均最短直径,核椭圆形因子(NEF)和形状因子(FF)与膀胱肿瘤的病理分级和分期有密切的关系。高分化或浅表性膀胱肿瘤的核平均面积和核平均最短直径较小,FF数值也较低;而低分化或浸润性膀胱肿瘤的核平均面积,核平均最短直径和FF平均显增高。上述定量性参数与膀胱肿瘤复发和患者预后明显相关,其中核平均最短直径与膀胱肿瘤复发患者预后关系最大。在膀胱肿瘤复发判断上,核平均最短直径的敏感度和特异度分别为84.2％和92.3％,在膀胱肿瘤的预后估计上。核平均最短直径的敏感度乖巧特异变分别为79.2％和100％。
In this paper, 58 cases of bladder tumor paraffin-embedded specimens were detected by morphometric analysis. The results showed that the average nuclear area, the shortest average nuclear diameter, nuclear oval factor (NEF) and shape factor (FF) were closely related to the pathological grading and staging of bladder tumor. The average nuclear size and the shortest nuclear mean diameter of the well-differentiated or superficial bladder tumors were small and the FF values were also lower; whereas the average nuclear area, the shortest nuclear diameter and the mean FF of the poorly differentiated or invasive bladder tumors were significantly higher. The above quantitative parameters and bladder cancer recurrence and prognosis was significantly related to the core average shortest diameter of the recurrence of bladder cancer patients with the greatest prognosis. In the judgment of bladder tumor recurrence, the sensitivity and specificity of the average shortest core diameter were 84.2% and 92.3% respectively, which were estimated in the prognosis of bladder cancer. The sensitivity of the average shortest diameter of the nucleus was 79.2% and 100%, respectively.