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本工作在国内外首先采用结扎小白鼠双侧颈总动脉，以脑电波零电位作为判断全脑严重缺血的指标，结合结扎颈部软组织、人工控制压力，成功地复制出小白鼠全脑缺血／再灌注损伤模型，再灌后脑电波未见恢复，脑组织ＣＰＫ活性显著降低（Ｐ＜０．０５）。病理检查：神经细胞部分水肿，部分核固缩，神经胶质局限性疏松化。本模型在脑缺血／再灌注损伤的实验研究中值得应用。
This work is the first to use ligation of bilateral common carotid artery in mice at home and abroad to brain wave zero potential as a measure of global brain ischemia, combined with the ligation of the neck soft tissue, artificial pressure control, the successful replication of the whole mouse brain missing The model of blood / reperfusion injury showed no recovery of brain wave after reperfusion, and the CPK activity in brain tissue was significantly decreased (P <0.05). Pathological examination: partial edema of nerve cells, part of the nuclear pyknosis, loose glial limitations. This model is worthy of application in the experimental study of cerebral ischemia / reperfusion injury.