肿瘤抑制因子CYLD(Cylindromatosis,头帕肿瘤综合征蛋白)是一种去泛素化酶,cyld基因突变或者缺失导致圆柱瘤,并与多种肿瘤的发生、发展密切关联。CYLD通过自身去泛素化酶活性移除特定底物的K63连接的泛素链,并负调控包括NF-κB在内的多条信号通路。在生理条件下,通过磷酸化修饰和泛素化修饰,CYLD的蛋白表达量和活性受到严格的调控。CYLD与多种细胞学功能相关,如细胞运动和迁移、免疫和炎症反应、破骨细胞的形成等。 The tumor suppressor CYLD (Cylindromatosis) is a deubiquitinating enzyme. The mutation or deletion of cyld gene leads to the tumor of the tumor, which is closely related to the occurrence and development of various tumors. CYLD removes K63-linked ubiquitin chains of specific substrates by its own deubuclidase activity and negatively regulates multiple signaling pathways including NF-κB. Under physiological conditions, CYLD protein expression and activity are tightly regulated through phosphorylation and ubiquitination modifications. CYLD is associated with a variety of cytological functions such as cell motility and migration, immune and inflammatory responses, osteoclast formation, and the like.