妇女健康创议(WHI)研究证实,绝经后女性接受雌孕激素替代治疗将弊大于利,尽管雌孕激素替代治疗可能与绝经后女性罹患结肠直肠癌风险降低有关。本文意就接受雌孕激素替代治疗与绝经后老年女性新发结肠直肠癌危险以及肿瘤相关特征间关系进行了分析。对象与方法本文为 WHI 试验分支研究,共纳入40个医疗中心的16608例绝经后老年女性,年龄50～79岁。先期剔 Women’s Health Initiative (WHI) study confirms that postmenopausal women receiving estrogen and progesterone replacement therapy will do more harm than good, although estrogen and progesterone replacement therapy may be associated with reduced risk of colorectal cancer in postmenopausal women. This article intends to analyze the relationship between estrogen and progesterone replacement therapy and the risk of newly diagnosed colorectal cancer in elderly women after menopause. Subjects and Methods In this study, the WHI pilot study included 16,608 postmenopausal elderly women in 40 medical centers aged 50-79 years. Early tick