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近十年来,非甾体消炎药(NSAIA)的构效关系与作用机制的研究取得了重大进展,临床应用范围不断扩大。据不完全统计,目前已经或正在临床应用和试用的药物有60余种。较新的NSAIA多是羧酸类,如乙酸、丙酸、邻氨苯甲酸、吲哚乙酸或吡咯乙酸等的衍生物。而颇为引人注目的则是一种结构完全不同于以上药物的苯噻嗪类的衍
In recent ten years, significant progress has been made in the study of the structure-activity relationship and mechanism of action of non-steroidal anti-inflammatory drugs (NSAIA), and its clinical application scope has been continuously expanded. According to incomplete statistics, currently there are more than 60 kinds of drugs that have been or are being used clinically and in trial. Newer NSAAs are mostly carboxylic acids, such as acetic acid, propionic acid, anthranilic acid, indoleacetic acid or pyrroleacetic acid and the like. The rather striking is a structurally different from the above drugs benzothiazines Yan Yan