在过去的60年中,尤其在过去的十年中,随着基因组研究上遗传指纹技术使用的增加和对环境因素影响的认识,2型糖尿病的异质性日益明显。在过去的十年里,治疗2型糖尿病的药物不断扩展,大样本随机对照试验蓬勃发展。虽然这些实验的设计目的是解决一些重要问题,但是反而产生了更多的难题,探讨2型糖尿病病理生理及治疗的各种方法的需要变得更加迫切。 Over the past 60 years, and particularly over the past decade, the heterogeneity of type 2 diabetes has become increasingly evident as the use of genetic fingerprinting techniques in genomics has increased and its implications for environmental factors have become increasingly apparent. Over the past decade, drugs to treat type 2 diabetes have been expanding and large randomized controlled trials have thrived. Although these experiments were designed to address some of the important issues, they created more problems than ever before and the need to explore various approaches to pathophysiology and treatment of type 2 diabetes became more urgent.