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乙型肝炎病毒感染人体可以引起急性和慢性乙型肝炎病毒感染。慢性乙型肝炎病毒感染后疾病的转归包括慢性肝炎、肝硬化、肝细胞癌以及肝衰竭。宿主、病毒因素及它们相互作用影响着疾病的进程。HBV基因突变导致病毒生物学特性改变是影响乙型肝炎病毒感染转归的重要因素之一。
Hepatitis B virus infection can cause acute and chronic hepatitis B virus infection in humans. Outcomes of diseases after chronic hepatitis B infection include chronic hepatitis, cirrhosis, hepatocellular carcinoma and liver failure. Host, viral factors and their interactions affect the course of the disease. HBV gene mutation lead to changes in the biological characteristics of the virus is one of the important factors affecting the outcome of hepatitis B virus infection.