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慢性炎症可导致动脉硬化,目前已经很清楚免疫细胞参与动脉硬化斑块的发病机制。白细胞的积聚和募集与动脉硬化斑块的形成有关,斑块的破裂可导致血栓、心梗或中风,最终导致死亡。斑块中绝大多数的巨噬细胞由单核细胞分化而来,单核细胞代表了循环系统中一类异质性的细胞群体。单核细胞在免疫系统的功能和炎症性疾病(如动脉硬化)中起着多重作用,而这些作用都涉及到细胞的运输和细胞迁移机制。本文回顾了近年来细胞因子在单核细胞迁移和渗出中作用的进展,着重介绍了主要的运输方式和调节单核细胞渗出的分子机制。
Chronic inflammation can lead to atherosclerosis, and it is now clear that immune cells are involved in the pathogenesis of atherosclerotic plaques. Leukocyte accumulation and recruitment are associated with the formation of atherosclerotic plaques, which can lead to thrombosis, myocardial infarction, or stroke, eventually leading to death. The vast majority of macrophages in plaques are differentiated by monocytes, which represent a heterogeneous population of cells in the circulatory system. Monocytes play multiple roles in the functioning of the immune system and in inflammatory diseases such as atherosclerosis, all of which involve cell trafficking and cell migration mechanisms. This review reviews recent advances in the role of cytokines in monocyte migration and exudation, highlighting the major modes of transport and the molecular mechanisms that regulate monocyte exocytosis.