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目的：探讨流行性出血热患者血清肾素活性（ＰＲＡ）、血管紧张素Ⅱ（ＡＴⅡ）、内源性类洋地黄物质（ＥＤＬＳ）和心房利钠因子（ＡＮＦ）变化及其临床意义。方法：６３例９７份标本及对照组２６例４种体液因子均采用放免法测定。结果：４种体液因子在ＥＨＦ各病期中与对照组相比均有升高，但以低血压休克期和少尿期升高最为显著（Ｐ＜０．０５），其中，ＡＮＦ少尿期高于低血压休克期（Ｐ＜０．０５），而ＥＤＬＳ则相反。相关分析显示ＰＲＡ、ＥＤＬＳ、ＡＮＦ和ＡＴⅡ与ＢＵＮ、Ｃｒ呈正相关（Ｐ＜０．０１）。结论：ＰＲＡ、ＡＴⅡ、ＥＤＬＳ和ＡＮＦ均参与ＥＨＦ的发病过程，尤其在急性肾衰过程中起着重要作用。
Objective: To investigate the changes of serum renin activity (PRA), angiotensin Ⅱ (ATⅡ), endogenous digitalisolide (EDLS) and atrial natriuretic factor (ANF) in patients with epidemic hemorrhagic fever and its clinical significance. Methods: 97 samples of 63 cases and control group of 26 cases of four humoral factors were determined by radioimmunoassay. Results: The four humoral factors increased in all stages of EHF compared with the control group, but were significantly higher in hypotension and oliguria (P <0.05). Among them, the rate of ANF oliguria In hypotensive shock (P <0.05), EDLS was the opposite. Correlation analysis showed that PRA, EDLS, ANF and AT Ⅱ and BUN, Cr was positively correlated (P <0.01). Conclusion: PRA, AT Ⅱ, EDLS and ANF are involved in the pathogenesis of EHF, especially in acute renal failure plays an important role.