报道了一种无需催化剂一锅法制备喹唑啉类化合物的新方法,制备的15个喹唑啉化合物中,其中有3个新化合物,收率在37%~95%.探讨了溴代烃的电子效应和空间位阻效应对反应的影响,提出了可能涉及重复亲核加成、消除生成喹唑啉的新机理,并因此而扩展到用酸酐代替N,N-二甲基甲酰胺(DMF)的反应. A new method for preparing quinazoline compounds without one-pot catalyst was reported. Among the 15 quinazoline compounds prepared, three new compounds were obtained in 37% ~ 95% yield. The effects of brominated hydrocarbons The electronic and steric hindrance effects on the reaction suggest a new mechanism that may involve repeated nucleophilic additions to eliminate the production of quinazoline and therefore extend to the use of anhydrides instead of N, N- dimethylformamide DMF).