左旋多巴(L-D)治疗巴金森氏病迄今已近20年,其疗效远较其他药物为佳,且被认为是神经病学上的一个划时代的治疗方法.但经过多年的观察,发现诸多问题.有人经过长期的治疗观察,认为治疗后5年的病例有1/3效果仍良好,1/3效果已差但尚能控制,1/3治疗失败.本文将就L-D长期治疗中所遇到的运动障碍;精神障碍;“开关”现 The treatment of Parkinson’s disease with levodopa (LD) for nearly 20 years has been far more effective than other drugs and is considered to be a landmark neurological treatment, but many years of observation have revealed many problems. It was observed after a long period of treatment, that 1/3 of the 5 years after treatment is still good results, 1/3 the effect has been poor but still able to control the failure of 1 / 3. This article will be LD long-term treatment encountered Dyskinesia; Mental disorders; “Switch ” Now