论文部分内容阅读
目的探讨Ⅰ型胶原羧基端交联肽(CTX)在慢性牙周炎病程中的作用。方法选择慢性牙周炎患者的第一磨牙共28颗进行基础治疗,采用滤纸条法采集龈沟液样本,CTX ELISA试剂盒测定龈沟液中CTX浓度。分别在慢性牙周炎基础治疗前、基础治疗后1个月、基础治疗后2个月采集龈沟液样本,观察龈沟液体积和CTX浓度变化。结果从慢性牙周炎基础治疗前至治疗后1个月及治疗后2个月龈沟液体积减少,CTX浓度逐渐降低,差异均有统计学意义(P<0.05)。结论龈沟液CTX的检测有可能成为监测牙周组织破坏程度重要参考指标。
Objective To investigate the role of type Ⅰ collagen carboxyterminal cross-linking peptide (CTX) in the pathogenesis of chronic periodontitis. METHODS: A total of 28 first molar patients with chronic periodontitis were selected for primary treatment. Samples of gingival crevicular fluid were collected using filter paper strip method. CTX ELISA kit was used to determine the concentration of CTX in gingival crevicular fluid. The gingival crevicular fluid samples were collected before the basic treatment of chronic periodontitis, one month after the basic treatment and two months after the basic treatment, and the changes of the volume of GCF and the concentration of CTX were observed. Results The volume of GCF was decreased and the concentration of CTX was gradually decreased from baseline before treatment to 1 month after treatment and 2 months after treatment. The difference was statistically significant (P <0.05). Conclusion The detection of CTX in gingival crevicular fluid may become an important reference index for monitoring the destruction of periodontal tissue.