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将雄性Wistar大鼠12只分成实验组和对照组.实验组行手术切断左侧颈交感干,两天后与对照组同时腹腔注射维生素D60万单位/kg体重(诱发动脉粥样硬化),存活20天后取双侧颈总动脉作石蜡切片、HE染色,光镜下观察,结果发现:实验组颈总动脉壁明显增厚,相当于正常血管壁的3～5倍,弹性纤维结构不清,甚至消失,内膜下层水肿并有胶原纤维增生,中膜有大量平滑肌细胞增生,其细胞核排列紊乱.对照组颈总动脉壁除内膜有些凹凸不平,中膜有轻度平滑肌细胞增生外,其它结构完整、血管壁厚度无明显增厚.结果证实动脉失去交感神经支配后,诱发动脉粥样硬化的形成明显加快.提示交感神经对动脉粥样硬化的形成可能具有一定调控作用.
Twelve male Wistar rats were divided into experimental group and control group.The experimental group was operated to cut off the left cervical sympathetic trunk, and two days later the control group were intraperitoneally injected with vitamin D 6 million units / kg body weight (inducing atherosclerosis) and survived 20 Days after the bilateral common carotid artery for paraffin sections, HE staining, light microscopy, the results showed that: the experimental group of common carotid artery wall thickening, equivalent to normal vessel wall 3 to 5 times, elastic fiber structure is unclear, or even Disappeared, subendothelial edema and collagen fibrosis, a large number of smooth muscle cell proliferation in the media, the arrangement of the nuclear disordered. In the control group of common carotid artery wall some uneven intima, medium with mild smooth muscle cell proliferation, the other structures Intact, there was no significant thickening of the vascular wall thickness.It was proved that the formation of atherosclerosis evoked by arterial loss of sympathetic innervation significantly accelerated, suggesting that sympathetic nerve may play a role in the regulation of atherosclerosis.