Chymostatin和 Pepstatin能分别抑制申克孢子丝菌产生的蛋白酶 和 ,为了证明在孢子丝菌病中 Chymostatin和 Pepstatin能通过抑制这些酶的活性而抑制真菌的生长 ,我们研究了在小鼠的皮损上外用蛋白酶抑制剂的效应 ,用 0 .1% Chymostatin,0 .1% pepstatin和 0 .1% chymostatin+0 .1%pepstatin软膏涂于无毛小鼠的申克孢子丝菌接种部位与对照组相比 ,单用一种成分时 ,皮损处结节大小的变化曲线表现分轻度抑制 ,而用含 chymostatin和 pepstatin的软膏 ,则强烈地抑制了结节的形成。本研究不仅证明了两种蛋白酶对申克孢子丝菌在体内生长的作用 ,而且还发展了一种新的局部药物治疗方法 Chymostatin and Pepstatin were able to inhibit the proteases produced by Spirillum & lt; (R) & gt; respectively, and in order to demonstrate that Chymostatin and Pepstatin can inhibit the growth of fungi by inhibiting the activity of these enzymes in sporotrichosis, we investigated the effect of Topical application of protease inhibitor effect, with 0. 1% Chymostatin, 0.1% pepstatin and 0.1% chymostatin + 0. 1% pepstatin ointment applied to hairless mice Shen Fusi inoculum and control group phase When compared with only one component, the nodule size curve at the lesion site showed mild inhibition, whereas the nidus formation was strongly inhibited with the ointment containing chymostatin and pepstatin. This study not only demonstrated the effect of two proteases on the growth of S. schenckii in vivo, but also developed a new method of topical drug treatment