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维甲酸或全反式维甲酸(RA)在诱导治疗急性早幼粒细胞白血病(APL)达完全缓解过程中,出现的一些较严重的副作用,如维甲酸综合征、皮肤干燥等,已有很多报道。最近,在应用RA治疗APL患者完全缓解后骨髓干抽,活检发现骨髓有胶原纤维增多。为了阐明RA引起骨髓胶原纤维增多的病理生理机制,作者对13例应用RA的APL患者进行研究。 病人和方法 13例APL患者均有染色体t(15;17)易位或PML/RARa基因重排。年龄19～63岁,男7
Retinoic acid or all-trans retinoic acid (RA) has a number of more serious side effects such as retinoid syndrome, dry skin, etc. during the induction of complete remission of acute promyelocytic leukemia (APL). Reported. Recently, after the complete remission of APL patients treated with RA, bone marrow dry extraction was performed and biopsy showed increased collagen fibers in the bone marrow. In order to elucidate the pathophysiological mechanism of RA causing bone marrow collagen fibers, the authors studied 13 patients with APL who were treated with RA. Patients and Methods All 13 APL patients had chromosome t (15; 17) translocation or PML/RARa gene rearrangements. Age 19 to 63, male 7