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针对神经科学基础研究对神经信息检测仪器的迫切需求,研制了双模态神经信息检测分析仪器。该检测仪由中央控制模块、电生理检测模块、电化学检测模块、数据采集模块及多通道神经信息分析处理软件组成,能实现128通道神经电生理信号和8通道神经电化学信号的检测。采用模拟神经信号发生器对该分析仪进行了电生理检测模块性能测试,能实时检测、分析处理128通道的微弱神经电生理信号,提取的Spike信号峰-峰值为320μV。结合64通道离体微电极阵列,采用电化学循环伏安扫描可实现对不同浓度抗坏血酸溶液的检测。实验结果表明,该分析仪能实现对微弱神经电生理和递质电化学信号的检测,为神经信息双模检测奠定了技术基础。
In view of the urgent need of nerve information detection instruments in the basic research of neuroscience, a bimodal nerve information detection and analysis instrument was developed. The detector consists of a central control module, an electrophysiological detection module, an electrochemical detection module, a data acquisition module and a multi-channel neural information analysis and processing software, which can detect 128 channels of electrophysiological signals and 8 channels of neural electrochemical signals. The analyzer was tested with the electrophysiological detection module by simulated nerve signal generator, which could detect and analyze 128 channels of weak electrophysiological signals in real time. The peak value of extracted Spike signal was 320μV. Combined with 64-channel in vitro microelectrode array, electrochemical cyclic voltammetry can be used to detect different concentrations of ascorbic acid solution. The experimental results show that the analyzer can detect the electrophysiological and neurochemical signals of weak nerves and lay the technical foundation for the dual-mode detection of neural information.