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本文对我院1985年至1991年从药品不良反应监察工作中以“自愿呈报”的方法收集到219份药品不良反应报告作总结分析。发生药品不良反应的药品种类前五位排列为:抗生素,中枢神经系统药,磺胺及其它抗菌药,血液生化生物制品、水、电解质平衡药。药品不良反应的临床表现前五位排列为:皮肤损害,致热反应、耳鸣头痛头晕、过敏性休克、昏厥和栓塞性毒性反应。因果关系分析:肯定10例,很可能147例,可能58例、可疑4例。指出了药品不良反应监察工作的重要性。
This article from 1985 to 1991 in our hospital from adverse drug reaction monitoring work to “voluntary reporting” method to collect 219 reports of adverse drug reactions for a summary analysis. The first five categories of drug adverse reactions occurred were antibiotics, CNS drugs, sulfa and other antibacterials, blood biochemicals, water and electrolyte balance drugs. The top five clinical manifestations of adverse drug reactions are as follows: skin lesions, pyrexia, tinnitus headache dizziness, anaphylactic shock, syncope and embolic toxic reactions. Causality analysis: 10 cases are positive, 147 cases are likely, 58 cases may be suspected, 4 cases suspicious. Pointed out the importance of drug adverse reaction monitoring work.