组合化学于上世纪90年代初出现在美国,在近十几年逐渐发展并成熟起来,其概念和技术已被广泛接受并用于科学研究的各个方面。美国化学文摘(CA)自1994年设立组合化学主题以来,收录的文献数一年比一年多,其中许多文章发表在著名的杂志。《Science》1998年把它列为科学研究领域的九大突破 Combinatorial chemistry appeared in the United States in the early 1990s and gradually developed and matured in the past decade. Its concepts and technologies have been widely accepted and used in all aspects of scientific research. The United States Chemical Abstracts (CA) has included more than a year in literature since the establishment of the combinatorial chemistry theme in 1994, many of which were published in prestigious magazines. Science ranked it as a nine breakthrough in the field of scientific research in 1998