小鼠口饲苦参液或将氧化苦参碱直接作用于脾细胞均不影响IgE抗体形成。氧化苦参碱明显抑制变应原诱导的肥大细胞脱颗粒作用,其抑制效应与药物浓度呈正相关。氧化苦参碱不阻断抗原与特异性抗体结合,亦不改变细胞内cAMP水平,但能降低细胞膜的流动性,稳定细胞膜。后者可能是苦参抑制肥大细胞释放组织胺治疗Ⅰ型变态反应的药理学基础。 Oral matrine in mice fed matrine or oxymatrine directly on the spleen cells did not affect the formation of IgE antibodies. Oxymatrine significantly inhibited allergen-induced mast cell degranulation, and its inhibitory effect was positively correlated with drug concentration. Oxymatrine does not block antigen binding with specific antibodies, does not change the level of intracellular cAMP, but can reduce the fluidity of the cell membrane, cell membrane stability. The latter may be Sophora flavescens inhibits the release of histamine mast cells to treat type Ⅰ allergic pharmacological basis.