论文部分内容阅读
目的:探讨胸腺肽α1(Tα1)免疫调节辅助治疗高龄老年肺部感染的临床作用,观察评估细胞免疫功能T淋巴细胞亚群(CD3+、CD3+CD4+、CD3+CD8+、CD4+/CD8+)指标动态变化与临床疗效。方法:入选≥80岁高龄老年肺炎患者70例,随机分为治疗组(Tα1组)和对照组,每组各35例。Tα1组使用基础治疗(抗感染、袪痰、平喘、对症治疗)+Tα1注射液1mg,皮下注射,1次/d,2周为一个疗程。对照组35例仅使用基础治疗。两组治疗前后对比观察外周血T淋巴细胞亚群(CD3+、CD3+CD4+、CD3+CD8+、CD4+/CD8+)免疫指标及临床疗效。结果:疗程结束后结果显示,Tα1组各项免疫指标明显改善提高,优于对照组(P<0.05)。临床疗效观察总有效率Tα1组94.3%;高于对照组82.6%,两组比较有统计学差异(P<0.05)。结论:Tα1辅助治疗高龄老年肺部感染可有效调节增强细胞免疫功能,促进肺部炎症吸收,改善预后。
Objective: To investigate the clinical effect of Thymosin α1 (Tα1) immunotherapy in adjuvant treatment of senile pulmonary infection in elderly patients and to evaluate the dynamic change of the indexes of cellular immune function T lymphocyte subsets (CD3 +, CD3 + CD4 +, CD3 + CD8 +, CD4 + / CD8 + Clinical efficacy. Methods: Seventy patients with senile pneumonia aged≥80 years old were randomly divided into treatment group (Tα1 group) and control group (35 cases in each group). Tα1 group using the basic treatment (anti-infection, sputum, asthma, symptomatic treatment) + Tα1 injection 1mg, subcutaneous injection, 1 / d, 2 weeks for a course of treatment. 35 cases in the control group only used basic treatment. The immune indexes and clinical effects of T lymphocyte subsets (CD3 +, CD3 + CD4 +, CD3 + CD8 +, CD4 + / CD8 +) in peripheral blood were compared between the two groups before and after treatment. Results: After the treatment, the results showed that all the immune indexes of Tα1 group improved obviously, which was better than the control group (P <0.05). The total effective rate of clinical observation Tα1 group 94.3%; 82.6% higher than the control group, the two groups were statistically significant (P <0.05). Conclusion: Tα1 adjuvant treatment of elderly elderly patients with lung infection can effectively regulate and enhance cellular immune function, promote lung inflammation absorption and improve prognosis.