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目的 研究肾细胞癌组织中核转录因子κB(NF κB)的表达及意义。方法 应用免疫组织化学S P法检测5例正常肾组织、1 8例癌旁肾组织和 40例肾细胞癌组织中NF κB的表达 ,并分析NF κB表达与肾细胞癌病理类型的关系。结果 5例正常组织和 1 8例癌旁肾组织均有NF κB的表达 ,在肾小管上皮细胞的胞质表达较强 ,肾小球毛细血管球和肾小球囊壁层细胞表达较弱。在 40例肾细胞癌组织中 ,NF κB主要表达于癌细胞的胞质和部分癌细胞的胞核。结论 正常肾组织和癌旁肾组织中 ,NF κB存在于肾小管上皮细胞的胞质 ,而癌细胞在胞质和 /或胞核。肾癌细胞核中表达的是NF κB家族p65/p50成员 ,它可能在肾细胞癌的发生、发展中起一定作用
Objective To study the expression and significance of nuclear factor kappa B (NF-κB) in renal cell carcinoma. Methods Immunohistochemical SP method was used to detect the expression of NF-κB in 5 normal renal tissues, 18 adjacent tissues and 40 renal cell carcinomas. The relationship between the expression of NF-κB and the pathological types of renal cell carcinoma was analyzed. Results The expression of NF-κB was detected in 5 normal tissues and 18 adjacent tissues. The cytoplasm of renal tubular epithelial cells was strongly expressed, and the expressions of glomerular capillary and glomerular parietal cells were weak. In 40 cases of renal cell carcinoma, NFκB mainly expressed in the cytoplasm of cancer cells and some of the cancer cells. Conclusion NF-κB is present in the cytoplasm of renal tubular epithelial cells in normal and paracancer tissues, while the cancerous cells are in the cytoplasm and / or nucleus. The expression of NF-κB family member p65 / p50 in the nucleus of renal cell carcinoma may play a role in the occurrence and development of renal cell carcinoma