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目的了解日照市HFMD的流行特征,为日照市手足口病的防治提供实验室病原学依据。方法对2010年-2016年日照市疾病预防控制中心收集的1 870份手足口病患者的粪便、咽拭子标本,通过荧光定量PCR方法进行肠道病毒核酸检测。结果 2010年-2016年共检测标本1 870份,其中核酸检测阳性标本1 533份,总阳性率为81.98%,其中EV71型病毒568份,占阳性总数的37.05%,CA16型519份,占阳性总数的33.86%,其他类型肠道病毒446份,占阳性总数的29.09%。结论导致手足口病流行的肠道病毒在每年的流行过程中的组成不同,有一定的规律,在男女患儿中的分布也不完全相同,同时在咽拭子和粪便中的分布也不相同。
Objective To understand the epidemiological characteristics of HFMD in Rizhao City and provide laboratory etiological evidence for prevention and treatment of HFMD in Rizhao City. Methods The stool and throat swab samples of 1 870 hand, foot and mouth disease patients collected from Rizhao Municipal Center for Disease Control and Prevention from 2010 to 2016 were tested for the presence of enterovirus nucleic acid by fluorescence quantitative PCR. Results A total of 1 870 samples were detected from 2010 to 2016, of which 1 533 were positive for nucleic acid detection. The total positive rate was 81.98%, of which 568 were EV71 viruses, accounting for 37.05% of the total positives and 519 CA16s, accounting for positive The total number of 33.86%, other types of enterovirus 446, accounting for 29.09% of the total number of positive. Conclusions The enterovirus which causes the HFMD epidemic is different in the course of the annual epidemic. It has a certain regularity, and the distribution is not the same in both sexes, and the distribution in the throat and feces is also different .