甾体类避孕药作为一种广泛、长期使用的生育控制药物,对服药者及其停药后生育的子代会不会产生遗传毒理效应,这一问题已引起人们的关注。近十多年来,随着遗传毒理学的迅速发展,国内外学者在不同水平上探讨了甾体类避孕药的致变(即诱变)、致畸和致癌作用。大量的文献报道和激烈的争论又促进这一主题的研究。本文试对这类研究中典型的、有争议的文献综述如下。 As a widely used and long-term fertility control drug, steroid contraceptives will not cause genotoxic effects on drug users and their offspring after childbirth. This issue has aroused people’s attention. In recent ten years, with the rapid development of genotoxicity, scholars at home and abroad have explored the mutagenesis (mutagenesis), teratogenicity and carcinogenesis of steroid contraceptives at different levels. A large number of reports and heated arguments have contributed to the research on this topic. This paper tries to summarize the typical and controversial literature in this type of research as follows.