早在1939年就已知道雌激素有抑制排卵作用,但它作为避孕药而被广泛使用还仅是近十余年的事。药物的避孕效果是肯定的,但存在的问题却引起了不少科研工作者的关注,并进行了多方面的实验研究。近几年来,对这类药物的遗传学效应研究大多集中于服药者的外周血淋巴细胞染色体畸变方面,而对停药后不久妊娠的胎儿染色体研究尚不多见。本文试对该领域的近年研究工作综述如下。 As early as 1939, estrogen has been known to inhibit ovulation, but it is only used for more than ten years as a contraceptive. The contraceptive effect of the drug is affirmative, but the existing problems have aroused the concern of many scientific researchers and carried out many experimental studies. In recent years, most of the studies on the genetics of these drugs have focused on the chromosomal aberrations of peripheral blood lymphocytes in patients taking drugs. However, the study of fetal chromosomes in pregnancy is still rare. This paper tries to summarize the recent research work in this field as follows.