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目的研究柴胡疏肝散加减方对三阴性乳腺癌患者无病生存率、总生存率的影响。方法选取经术后病理组织学确诊为三阴乳腺癌、且术后均需要行辅助化疗的I期、II期患者100例,以数字法随机分成对照组和治疗组各50例。对照组术后施以AC-T方案辅助化疗;治疗组则在对照组基础上服用中药柴胡疏肝散加减方维持治疗。结果治疗组5年无病生存率占比为62%(31/50),总生存率为90%(45/50),均显著高于对照组的42%(21/50)和74%(37/50);治疗组死亡率10%(5/10)明显低于对照组的26%(13/50),差异均具有统计学意义(P<0.05)。结论三阴乳腺癌患者术后化疗后,通过服用柴胡疏肝散加减方维持治疗,能有效提高患者5年无病生存率、总生存率,减少复发转移率,延长患者生存期。
Objective To study the effect of Chaihu Shugan San addition and subtraction on the disease-free survival rate and overall survival rate of triple negative breast cancer patients. Methods Totally 93 patients with triple-negative breast cancer diagnosed by postoperative histopathology and 100 patients with stage I and II need adjuvant chemotherapy after operation were randomly divided into control group and treatment group (50 cases) by digital method. The control group was given AC-T regimen adjuvant chemotherapy; the treatment group was on the basis of the control group taking traditional Chinese medicine Chaihu Shugan Powder plus maintenance therapy. Results The 5-year disease-free survival rate in the treatment group was 62% (31/50) and the overall survival rate was 90% (45/50), which were significantly higher than those in the control group (42%, 21/50) and 74% 37/50). The mortality rate in the treatment group was significantly lower than that in the control group by 10% (5/10) and 26% (13/50) respectively. The differences were statistically significant (P <0.05). Conclusions After the operation of chemotherapy for the patients with triple-negative breast cancer, the maintenance treatment of Chaihu Shugan San decoction can effectively improve the 5-year disease-free survival rate, overall survival rate, reduce the recurrence and metastasis rate, and prolong the survival of patients.