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经手术切除的134例原发性肺癌组织,用刀豆凝集素-辣根过氧化物酶(ConA-HRP)定位技术观察刀豆凝集素(ConA)受体的分布。癌细胞内ConA受体可见于核膜、质膜及细胞质内,其分布与组织学类型有关,鳞癌核膜上ConA受体阳性反应高于腺癌,而腺癌细胞质内ConA受体高于鳞癌。组织学分级与鳞癌质膜ConA受体呈负相关(P<0.01),而腺癌与细胞质内受体分布呈正相关(P<0.05),未分化癌主要见于核膜上。未发现ConA受体的分布与患者预后之间有联系。
134 surgically resected primary lung cancer tissues were used to observe the distribution of the ConA acanthine receptor (ConA-HRP) using a concanavalin aggrecan-horseradish peroxidase (ConA-HRP) mapping technique. In cancer cells, ConA receptors are found in the nuclear membrane, plasma membrane, and cytoplasm. Their distribution is related to the type of histology. ConA receptor positive reaction on the nucleus membrane of squamous cell carcinoma is higher than adenocarcinoma, and ConA receptors in adenocarcinoma cells are higher than those in adenocarcinoma cells. Squamous cell carcinoma. The histological grade was negatively correlated with ConA receptors in the plasma membrane of squamous cell carcinoma (P<0.01), but adenocarcinoma was positively correlated with the distribution of cytoplasmic receptors (P<0.05). Undifferentiated carcinomas were mainly found on the nuclear membrane. No association was found between the distribution of ConA receptors and the prognosis of patients.