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骨质疏松是一种发病率高而病因不明的病。绝经后的雌激素缺乏在发病中起重要作用,其它可能的病因包括钙的缺乏,1,25-二羟基维生素 D_3循环水平的降低,轻度肾功能不全引起的继发性甲状旁腺功能亢进,成熟期骨总量降低和高蛋白饮食。对钙缺乏在人骨质疏松时的作用是有争论的。因为钙的摄入或小肠钙的吸收都与小肠乳糖酶的活性有关,所以骨质疏松患者的缺钙归咎于乳糖酶缺乏是一大贡献。Birge 等(1967)在19例骨质疏松患者中有9例乳糖吸收降低,Newcomer 等人报告在妇
Osteoporosis is a disease with a high incidence but unknown etiology. Postmenopausal estrogen deficiency plays an important role in the pathogenesis. Other possible causes include lack of calcium, reduction of circulating 1,25-dihydroxy vitamin D 3 levels, secondary hyperparathyroidism due to mild renal insufficiency , Mature bone mass decreased and high protein diet. The role of calcium deficiency in human osteoporosis is controversial. Because calcium intake or intestinal calcium absorption are related to the activity of small intestine lactase, so calcium deficiency in patients with osteoporosis due to lack of lactase is a major contribution. Birge et al. (1967) reduced lactose uptake in 9 of 19 osteoporosis patients. Newcomer et al.