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建立了超高效液相色谱串联质谱(UPLC-MS/MS)同时测定饮用水中49种药物与个人护理品(PPCPs)残留的方法。采用Oasis HLB固相萃取柱对水样中的目标化合物进行富集净化,用液相色谱-串联质谱法进行分离和检测,以ACQUITY UPLC HSS T3色谱柱分离,以甲醇和0.1%甲酸水溶液为流动相进行梯度洗脱,质谱采用电喷雾正离子电离、多反应监测模式检测,内标法定量。结果表明,49种药物与个人护理品在生活饮用水中的三种不同加标量下的回收率分别为50.3%~124.5%、61.7%~123.3%和64.3%~124.6%,相对标准偏差(n=6)分别为1.1%~15.5%、0.3%~11.3%和0.9%~8.2%;最低检测质量浓度在0.05~5.73 ng/L之间。将建立的方法应用于北京某地表水、地下水以及市政水水样的分析,结果表明,该法操作简单、灵敏度高、选择性强,适用于饮用水中药物与个人护理品残留的测定。
A method for the simultaneous determination of 49 drugs and personal care products (PPCPs) in drinking water by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS) was established. The target compounds in water samples were purified by Oasis HLB solid phase extraction column, separated and detected by liquid chromatography-tandem mass spectrometry, separated by ACQUITY UPLC HSS T3 column, and flowed with methanol and 0.1% formic acid aqueous solution Phase gradient elution, mass spectrometry electrospray positive ionization, multi-reaction monitoring mode detection, internal standard method. The results showed that the recoveries of three drugs and personal care products in drinking water were 50.3% -124.5%, 61.7% -123.3% and 64.3% -124.6%, respectively. The relative standard deviations (n = 6) were 1.1% ~ 15.5%, 0.3% ~ 11.3% and 0.9% ~ 8.2%, respectively. The lowest detection concentration was between 0.05 ~ 5.73 ng / L. The method was applied to the analysis of surface water, groundwater and municipal water samples in Beijing. The results showed that the method was simple, sensitive and selective. It was suitable for the determination of residues of drugs and personal care products in drinking water.