本文系一系列研究改变米拉雪耳(Miracil)类化合物(Ⅰ)的结构,以寻求治疗日本血吸虫病药物的一部分.据前人报告,米拉雪耳类化合物的结构中,4-甲基及1-二乙氨基乙氨基甚为重要,若变更这些基团的位置或以其他基团取代,则对曼氏血吸虫病的疗效印显著减弱或消失.本文保持了米拉雪耳类化合物的有效部分,将苯圜切除,制各5-二乙氨乙氨基-4-甲基-苯并氧六圜-4-酮盐酸盐(Ⅱ),供日本血吸虫病动物疗效试验 This article is a series of studies to change the structure of the Miracil compound (I) in order to seek treatment for schistosomiasis japonicus part of the drug.According to previous reports, the structure of the Mirabilis compounds, 4-methyl And 1 - diethylaminoethylamino is very important, if you change the position of these groups or replace with other groups, then the treatment of Schistosoma mansoni significantly reduced or disappeared.In this article, Effective part, the benzodiazepine excision, the system of 5-diethylaminoethylamino-4-methyl-benzoxan-4-one hydrochloride (II) for the Japanese schistosomiasis animal efficacy test