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本文首次在国内用自制YED-1型自动注射泵脉冲式皮下注射LHRH(5μg/脉冲/90分)治疗4例低促性腺激素型性功能低下(IHH)。所有4例经治疗后症状明显改善,性激素水平明显提高,睾丸体积增大,其中2例达正常成年男子水平,并在治疗的第250和330天时精液中出现成熟精子,精子计数分别为4×10~6/ml和10×10~6/ml,第3例睾丸由治前的4ml增大到8ml。2例已结婚。第4例经治疗4个月,症状及激素水平明显好转后,出现耐药现象,血清T水平又下降到治疗前的极低水平,阴茎停止勃起,推测可能与出现抗LHRH抗体有关。
This article for the first time in the country with a homemade YED-1-type auto-injection pump pulse subcutaneous injection of LHRH (5μg / pulse / 90 minutes) treatment of 4 cases of gonadotropin-type hypogonadism (IHH). All four patients showed significant improvement in symptoms, increased sex hormone levels, increased testicular volume, and 2 of them reached normal adult male levels. Mature spermatozoa appeared on the 250th and 330th days of treatment with sperm counts of 4 × 10 ~ 6 / ml and 10 × 10 ~ 6 / ml, the third case of testicular by the pre-treatment 4ml increased to 8ml. 2 cases have been married. The fourth case after 4 months of treatment, symptoms and hormone levels improved significantly after the emergence of drug resistance, serum T level dropped to the very low level before treatment, penile erection, presumably with the emergence of anti-LHRH antibodies.