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目的:探讨四种微量元素铜(Cu)、锌(Zn)、铁(Fe)、铬(Cr)与糖尿病(DM)及糖尿病肾病(DN)之间的关系,研究微量元素在DM发生、发展中的作用。方法:同时测定98例DM患者,DM、DN肾功能正常组53例,DM、DN肾功能不全组33例,正常对照组60例的微量元素铜(Cu)、锌(Zn)、铁(Fe)、铬(Cr)的值及肌酐(Cr)、尿素(BUN)、胱抑素C(Cy-sC)及内生肌酐清除率(CCr)的值。结果:DM组与对照组比较,铜高于正常对照组,锌、铁、铬低于正常对照组(P<0.05)。微量元素与血糖的相关性,除铜是正相关,锌、铁、铬均为负相关。DN肾功能不全组和DN肾功能正常组锌、铁、铬均低于正常对照组,铜高于正常对照组(P<0.05);DN肾功能不全组锌、铁均低于DN肾功能正常组(P<0.05)。结论:微量元素的检测,对DM的发生、发展,有效的预防并发症DN的发生,有一定的临床意义。
OBJECTIVE: To investigate the relationship between four trace elements Cu, Zn, Fe, Cr and diabetic nephropathy (DN), and to study the role of trace elements in the development of DM In the role. Methods: The clinical data of 98 patients with DM, 53 patients with normal function of DM and DN, 33 patients with dysfunction of DM and DN, 33 patients with dysfunction of kidney and 60 patients with normal control were studied. ), Chromium (Cr), creatinine (BUN), cystatin C (Cy-sC) and endogenous creatinine clearance (CCr) were measured. Results: Compared with the control group, copper in the DM group was higher than that in the normal control group, while zinc, iron and chromium in the DM group were lower than those in the normal control group (P <0.05). Trace elements and blood glucose, in addition to copper is a positive correlation, zinc, iron, chromium are negative correlation. The levels of zinc, iron and chromium in DN renal dysfunction group and DN normal renal function group were lower than those in normal control group and copper higher than those in normal control group (P <0.05). The levels of zinc and iron in DN renal dysfunction group were lower than those in normal renal function group Group (P <0.05). Conclusion: The detection of trace elements has a certain clinical significance for the occurrence and development of DM and effective prevention of the occurrence of DN.