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近年来由免疫学因素造成的不育已引起了人们的极大关注。最近的研究表明在原因不明性不育夫妇中有10～30%可能由于抗精子抗体(AsAb)所引致。早期的工作表明同种睾丸提取物免疫雄性豚鼠可导致睾丸炎及精子形成障碍。随后又从不育夫妇血清中查出抗精子抗体(AsAb)。此后,人们对精子的抗原性,AsAb的产生与检测、AsAb对受精过程及受精后的影响、及对由AsAb引起的免疫不育的诊断与治疗进行了大量的研究报道,本文综述了近年来上述各方面的研究进展。
In recent years, infertility caused by immunological factors has caused great concern. Recent studies have shown that 10-30% of infertile couples with unexplained reason may be caused by anti-sperm antibody (AsAb). Earlier work showed that immunization of male guinea pigs with the same kind of testicular extract can lead to orchitis and sperm formation disorders. Subsequently, anti-sperm antibodies (AsAb) were detected from the serum of infertile couples. Since then, a large number of studies have been carried out on the antigenicity of sperm, the production and detection of AsAb, the influence of AsAb on the fertilization process and after fertilization, and the diagnosis and treatment of immune sterility caused by AsAb. In this paper, The above aspects of research progress.