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目的:研究胰腺癌组织中Survivin和MMP14的表达及其临床病理意义,为筛选胰腺癌分子诊断新靶标提供理论依据。方法:采用免疫组织化学技术(S-P)法检测44例胰腺癌、13例胰腺炎及21例正常胰腺组织中Survivin和MMP14表达情况,并分析其与胰腺癌临床病理参数的相关性。结果:胰腺癌组织中Survivin和MMP14蛋白均呈明显高表达,其表达与胰腺癌患者的性别、年龄、肿瘤部位、临床分期、分级及有无淋巴结转移均显著相关性(P>0.05)。胰腺炎与正常胰腺组织中Survivin和MMP14蛋白表达的差异无统计学意义(P>0.05),但均显著低于胰腺癌组织(P=0.000/P=0.001)。结论:Survivin和MMP14蛋白在胰腺癌组织中均呈异常高表达,但与胰腺癌的临床病理特点均无关,可能成为新的胰腺癌诊断标志物。
OBJECTIVE: To study the expression of Survivin and MMP-14 in pancreatic cancer and its clinicopathological significance, and to provide a theoretical basis for screening new molecular targets of pancreatic cancer. Methods: The expressions of Survivin and MMP14 in 44 cases of pancreatic cancer, 13 cases of pancreatitis and 21 cases of normal pancreatic tissue were detected by immunohistochemical technique (S-P). The correlation between Survivin and MMP-14 expression and the clinicopathological parameters of pancreatic carcinoma was analyzed. Results: The expressions of Survivin and MMP14 protein in pancreatic cancer tissues were significantly higher than those in normal pancreatic cancer patients (P> 0.05). The expression of Survivin and MMP14 protein in pancreatic cancer tissues was significantly higher than that in normal pancreatic cancer patients. The expressions of Survivin and MMP14 in pancreatitis and normal pancreatic tissue were not significantly different (P> 0.05), but were significantly lower than those in pancreatic cancer (P = 0.000 / P = 0.001). CONCLUSIONS: Survivin and MMP14 protein are highly expressed in pancreatic cancer tissues, but have no correlation with clinicopathological features of pancreatic cancer, which may be a new diagnostic marker of pancreatic cancer.