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冠状动脉病变(冠脉病变)的进展将增加冠脉事件的风险,冠脉病变进展被认为是心源性死亡独立的预测因素。因此研究冠状动脉病变进展的机制、影响因素以及防治,对判断轻、中度冠脉狭窄患者是否需要强化药物治疗或及早经皮冠状动脉介入治疗(PCI),以及对冠心病患者的预后评价等可提供重要参考依据。冠脉病变进展的影响因素除了诸如患者的年龄、性别、吸烟等一般情况,对患者的发病方式及造影情况,近年来集中于糖尿病、血脂、C反应蛋白等方面的研究。对于如何稳定甚至逆转斑块,目前研究最透彻,应用最广泛、最有效的当属他汀类药物。但由于冠脉病变进展涉及多种机制,因此针对不同危险因素和机制的防治药物有待进一步发现。
The progression of coronary lesions (coronary lesions) will increase the risk of coronary events and progression of coronary lesions is considered as an independent predictor of cardiac death. Therefore, the study of the mechanism of coronary artery disease progression, factors and prevention, to determine whether patients with mild and moderate coronary stenosis need intensive drug treatment or early percutaneous coronary intervention (PCI), and prognosis of patients with coronary heart disease evaluation Can provide an important reference. In addition to factors such as the patient’s age, gender, smoking and other general conditions, the pathogenesis of coronary artery disease and angiography in recent years focused on diabetes, lipids, C-reactive protein and other aspects of research. For how to stabilize and even reversal of plaque, the most thorough study, the most widely used, the most effective belongs to statins. However, due to the progress of coronary lesions involving a variety of mechanisms, so for different risk factors and mechanisms of prevention and treatment of drugs to be further found.