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抑制HSC激活和ECM合成 ,促进ECM降解已成为抗肝纤维化治疗的重要途径。基质金属蛋白酶 (MMPs)是抑制ECM在肝脏内沉积的主要蛋白酶。研究证实 ,纤溶酶原由尿激酶型纤溶酶原激活剂 (uPA)激活形成纤溶酶后 ,可将以酶原形式分泌的MMPs裂解而激活。此外 ,纤
Inhibition of HSC activation and ECM synthesis, ECM degradation has become an important anti-fibrosis treatment approach. Matrix metalloproteinases (MMPs) are the major proteases that inhibit the deposition of ECM in the liver. Studies have shown that plasminogen activation by the urokinase-type plasminogen activator (uPA) to form plasmin, the enzyme can be secreted MMPs cleaved and activated. In addition, fiber