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患者46岁,39岁(1975年)时因发现皮疹而入院治疗。以后诊断为坏死性游走性红斑。无糖尿病家族史,以前曾患过急性胰腺炎。患者主诉和体检发现体重减轻(在入院前一年间减轻6公斤),轻度贫血,舌炎,脱毛,低蛋白血症以及葡萄糖耐量降低。血中氨基酸浓度明显减少(约下降至正常值的50%)。内分泌学检查发现空腹血高糖素(IRG)明显升高,达4000～8000pg/ml。给口服葡萄糖
Patients 46 years of age, 39 years old (1975) admitted to hospital for a rash. After the diagnosis of necrotizing migratory erythema. No family history of diabetes, previously had acute pancreatitis. Patients’ complaints and physical examination found weight loss (6 kg during the year prior to admission), mild anemia, glossitis, hair loss, hypoalbuminemia, and impaired glucose tolerance. Serum amino acid concentration was significantly reduced (down to about 50% of normal). Endocrinological examination found that fasting glucagon (IRG) was significantly elevated, reaching 4000 ~ 8000pg / ml. Give oral glucose