论文部分内容阅读
胃和十二指肠溃疡的发病机理可能是不同的。Duplesis于1965年首先提出幽门括约肌功能不全引起胆汁反流,后者在胃溃疡发病学上是很重要的因素。而十二指肠溃疡病者的壁细胞总量及分泌胃酸和胃蛋白酶的能力显著高于正常人,其发病可能与胃酸过高有关。迷走神经活动在溃疡病发生中起一定作用。鉴于消化性溃疡之病因,治疗原则:一是抑制攻击因子;即减少胃酸分泌和胃蛋白酶的活化,缓解疼痛。二是增强防御因子;即提高组织抵抗力和促进组织修复功能,促使溃疡愈合。目前临床使用的药物都是针对这些原则而起作用的。除沿用抗酸药及抗胆碱能药外,近几年来不断出现新药,其中以组织胺H_2
The pathogenesis of gastric and duodenal ulcers may be different. Duplesis first proposed in 1965 that pyloric sphincter insufficiency caused bile reflux, which is an important factor in the pathogenesis of gastric ulcer. The total number of parietal cells and secretion of gastric acid and pepsin in duodenal ulcer patients was significantly higher than normal, the incidence may be related to hyperacidity. Vagal activity plays a role in the development of ulcer disease. In view of the etiology of peptic ulcer, the treatment principle: First, inhibit the attack factor; that is, reduce gastric acid secretion and pepsin activation, relieve pain. The second is to enhance the defensive factor; that is, to improve tissue resistance and promote tissue repair function, promote ulcer healing. The current clinical use of drugs are based on these principles and work. In addition to the use of antacids and anticholinergics, in recent years there have been new drugs, including histamine H_2