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Objective: To study the effect of Danshao Huaxian capsule (丹芍化纤胶囊,DSHX), a traditional Chinese medical prescription, on the expression of collagen (Col) Ⅰ, Ⅲ and cysteinyl aspartate specific proteases-3 (caspase-3) in CCl4-induced hepatic fibrosis in rats. And also it is to explore the mechanism of DSHX in anti-fibrosis. Methods: Eighty male Wistar rats were randomly divided into the normal control group (A), the model group (B), the un-treated model group (C), the low-dose-DSHX treated group (D) and the high-dose-DSHX treated group (E). Except those in Group A, all the other rats were made into hepatic fibrotic models by comprehensive processes including subcutaneous injecting of CCl4, and feeding them with alcoholic high-fat and low-protein diet for 8 weeks. Then the two DSHX-treated groups were treated respectively with low dose (0.5 g/kg) and high dose (1.0 g/kg) DSHX capsule by gastrogavage everyday for 8 weeks. At the end of the experiment, the liver index, levels of hyaluronic acid (HA) an
Objective: To study the effect of Danshao Huaxian capsule (Danxiong chemical fiber capsules, DSHX), a traditional Chinese medical prescription, on the expression of collagen (Col) I, III and cysteinyl aspartate specific proteases-3 (caspase-3) in CCl4 Method: Eighty male Wistar rats were randomly divided into the normal control group (A), the model group (B), the un- The treated model group (C), the low-dose-DSHX treated group (D) and the high-dose-DSHX treated group (E). Except those in Group A, all the other rats were made into hepatic fibrotic models by comprehensive processes Then the two DSHX-treated groups were treated respectively with low dose (0.5 g/kg) and high dose (1.0 g/kg). ) DSHX capsule by gastrogavage everyday for 8 weeks. At the end of the experiment, the liver index, levels Of hyaluronic acid (HA) an