近年来在人体胆汁中发现了能溶解和转运胆固醇的胆固醇磷脂泡(简称泡),泡有很大的胆固醇溶解能力并与胆汁中胆固醇单水结晶的形成有密切的关系。胆固醇单水结晶是胆固醇结石的主要成分,目前认为它是过饱和胆汁在促成核因子的作用下,胆汁中泡发生融合和聚集的结果。本文将介绍泡的发现,形成、结构特点及与胆固醇单水结晶形成关系的研究近况。 In recent years, cholesterol phospholipid bubble (abbreviated as bubble) that can dissolve and transport cholesterol has been found in human bile, which has a great ability of dissolving cholesterol and is closely related to the formation of cholesterol monohydrate in bile. Cholesterol monohydrate crystallization is the main component of cholesterol stones, at present it is considered supersaturated bile in promoting the role of nuclear factor, bile foam fusion and aggregation results. This article will introduce the discovery, formation, structural features of bubbles and their relationship with the formation of cholesterol monohydrate crystals.