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目的了解许昌市痰菌培养阳性肺结核患者的耐药情况,为结核病控制策略提供依据。方法对许昌市结核病防治所2012年4月1日至2013年6月30日138例痰菌培养阳性肺结核患者的4种抗结核药物敏感性结果进行分析。结果 138例培养阳性肺结核患者中耐药的96例,耐药率为69.57%。其中初始耐药率为64.65%,获得性耐药率为82.05%(P<0.05);初始单一耐药率为29.29%,获得性单一耐药率为7.69%(P<0.05);初始耐多药率为8.08%,获得性耐多药率为43.59%(P<0.05)。结论许昌市结核病耐药情况比较严重,要进一步加强耐药结核病的监测。
Objective To understand the drug resistance of sputum culture positive tuberculosis patients in Xuchang City and provide the basis for tuberculosis control strategy. Methods To analyze the sensitivity of four anti-tuberculosis drugs in 138 patients with sputum culture-positive pulmonary tuberculosis from April 1, 2012 to June 30, 2013 in Xuchang Tuberculosis Prevention and Control Institute. Results Among the 138 patients with positive pulmonary tuberculosis, 96 cases were drug resistant with the drug resistance rate of 69.57%. The initial drug resistance rate was 64.65%, and the acquired drug resistance rate was 82.05% (P <0.05). The initial single drug resistance rate was 29.29% and the acquired single drug resistance rate was 7.69% (P <0.05) The drug rate was 8.08%, and the acquired multidrug resistance rate was 43.59% (P <0.05). Conclusion The drug resistance of tuberculosis in Xuchang City is rather serious, so it is necessary to further strengthen the surveillance of drug-resistant tuberculosis.