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光、电镜下对球蛋白紊乱血症伴浸润脑脊膜性多发性神经病、Dyck Ⅰ型先天性肥大型神经病、家族性淀粉样变性神经病、异染性脑白质营养不良、复发性多发性神经根炎及立克次氏体性血管炎性神经病等41例患者腓浅神经足背支活检标本中神经内膜血管进行了观察。结果发现血-神经屏障可有五种病理类型。(Ⅰ)内皮膜窗型或缺失型;(Ⅱ)内皮肿胀型;(Ⅲ)管壁增厚型;(Ⅳ)血栓形成型;(Ⅴ)混合型。这些改变影响神经内膜微环境,进而导致神经纤维和Schwann细胞的形态和功能改变。
Light and electron microscopy of globulin dyskinesia with infiltration of meningococcal polyneuropathy, Dyck type I congenital hypertrophic neuropathy, familial amyloidosis, idiopathic leukodystrophy, recurrent multiple nerve root Inflammation and Rickettsia vasculitis and other neuropathies in 41 patients with peroneal nerve dorsal pedunculated biopsy specimens of endoprosthetic vessels were observed. The results showed that blood-nerve barrier can have five pathological types. (Ⅰ) Endothelial membrane window type or deletion type; (Ⅱ) Endothelium swelling type; (Ⅲ) Thickening tube wall; (Ⅳ) Thrombosis; (V) Mixed type. These changes affect the neointimal microenvironment, leading to changes in the morphology and function of nerve fibers and Schwann cells.