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目的:对我国重症肺炎合并脓毒症病人的炎症因子与危重评分的相关性进行分析和研究。方法:将2016年2月至2017年3月之间,来我院就诊的重症肺炎合并脓毒症病人共计120例,使用危重病例评分法将其分成极危重组(<75分)、危重组(~85分)以及非危重组(>85分)。对这些病人的炎症因子(PLT、血WBC、IL-6以及CRP)进行检测,使用多元线性回归对炎症因子与危重评分相关性进行研究和分析。结果:三组病人随着危重评分值的减小,其IL-6、CRP呈现出逐渐升高;PLT技术呈现出降低;血WBC在各组件无统计学意义(P>0.05);差异有统计学意义(P<0.05)。结论:IL-6、可溶性P-选择素、PLT水平与重症肺炎合并脓毒症病人具有较高的相关性。
OBJECTIVE: To analyze and study the correlation between inflammatory factors and risk scores in patients with severe pneumonia complicated with sepsis in China. Methods: A total of 120 patients with severe pneumonia complicated with sepsis who visited our hospital from February 2016 to March 2017 were divided into critically ill patients (<75 points) and patients in critically ill patients (~ 85 points) and non-critically ill group (> 85 points). Inflammatory factors (PLT, blood WBC, IL-6, and CRP) were measured in these patients, and multivariate linear regression was used to investigate the association of the inflammatory markers with the risk score. Results: The levels of IL-6 and CRP increased gradually with the decrease of the critical score in the three groups, but decreased in the PLT group. There was no significant difference in WBC between the two groups (P> 0.05) Significance (P <0.05). Conclusion: The levels of IL-6, soluble P-selectin and PLT in patients with severe pneumonia complicated with sepsis have a high correlation.