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目的观察血清胱氨酸蛋白酶抑制剂C(Cystatin C,简称Cys C)在新生儿高胆红素血症中的变化,评价其对肾滤过功能的影响。方法应用酶联免疫吸附法(ELISA)对68例(观察组)新生儿高胆红素血症(轻度20例,中度26例,重度22例)及无黄胆(对照组)28例新生儿血清中Cys C的水平以及血肌酐、尿素氮进行测定,并采用SPSS11.0进行统计学方差分析和t检验。结果高胆红素血症组血肌酐、尿素氮与对照组比较差异无统计学意义,而新生儿高胆红素血症时Cys C水平升高,随着胆红素的消退,Cys C水平下降。结论新生儿高胆红素时肾小球滤过功能会受损,血Cys C是评价肾小球滤过功能敏感的检测指标。
Objective To observe the changes of serum cystatin C (Cys C) in neonatal hyperbilirubinemia and evaluate its effect on renal filtration function. Methods 28 cases of neonatal hyperbilirubinemia (mild 20 cases, moderate 26 cases, severe 22 cases) and 28 cases without jaundice (control group) were detected by enzyme-linked immunosorbent assay (ELISA) Neonatal serum Cys C levels and serum creatinine, urea nitrogen were measured, and using SPSS11.0 statistical analysis of variance and t test. Results Serum creatinine and urea nitrogen in hyperbilirubinemia group were not significantly different from those in control group, while the level of Cys C in neonates with hyperbilirubinemia was increased. With the decline of bilirubin, Cys C level decline. Conclusion Glomerular filtration function is impaired in neonates with hyperbilirubinemia. Cys C is a sensitive index for the evaluation of glomerular filtration function.