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目的:观察独活寄生汤对膝骨性关节炎患者关节滑液中细胞因子的影响,探讨其治疗骨性关节炎的作用机制。方法:选择膝骨性关节炎患者70例,随机分为治疗组和对照组,各35例,治疗组35例患者给予独活寄生汤治疗,对照组35例患者给予美洛昔康胶囊治疗,治疗6周。治疗前后分别测定两组患者膝关节滑液中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)和高敏C反应蛋白(hs-CRP)的水平。结果:治疗后,两组患者膝关节滑液中TNF-α、IL-1β和hs-CRP水平与治疗前比较显著下降(P<0.01);两组患者治疗后膝关节滑液中TNF-α、IL-1β和hs-CRP水平比较,差异有统计学意义(P<0.05或P<0.01)。结论:独活寄生汤能降低膝骨性关节炎患者关节滑液中TNF-α、IL-1β和hs-CRP的产生,从而抑制炎症因子对关节软骨的破坏,延缓关节软骨的退变。
Objective: To observe the effect of Dovestroke Decoction on cytokines in synovial fluid of patients with knee osteoarthritis and to explore its mechanism of action in the treatment of osteoarthritis. Methods: Seventy patients with knee osteoarthritis were randomly divided into treatment group (35 cases) and control group (35 cases). Treatment group (35 cases) was treated with Doxue parasitic soup (35 cases) and meloxicam capsule 6 weeks. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and high-sensitivity C-reactive protein (hs-CRP) were measured before and after treatment in both groups. Results: After treatment, the levels of TNF-α, IL-1β and hs-CRP in knee joint synovial fluid of two groups were significantly decreased compared with those before treatment (P <0.01) , IL-1β and hs-CRP levels, the difference was statistically significant (P <0.05 or P <0.01). Conclusion: Dovestroke Decoction can reduce the production of TNF-α, IL-1β and hs-CRP in synovial fluid of patients with knee osteoarthritis, thus inhibiting the destruction of articular cartilage by inflammatory cytokines and delaying the degeneration of articular cartilage.