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观察犬放射损伤时血浆与红细胞膜８－表氧－前列腺素Ｆ２α（８－表氧－ＰＧＦ２α）含量的改变，并与丙二醛（ＭＤＡ）比较，探讨测定８－表氧－ＰＧＦ２α对了解脂质过氧化反应的价值以及ＳＯＤ对其的影响。方法用６０Ｃｏγ射线照射１８只成年杂种犬，实验分低剂量ＳＯＤ组，高剂量ＳＯＤ组及对照组，每组６只，吸收剂量率为０．６Ｇｙ／ｄ，共５天，计３．０Ｇｙ。测定照射前、照射过程中及照射后血浆与红细胞膜８－表氧－ＰＧＦ２α及ＭＤＡ含量。结果在６０Ｃｏγ射线照射期间，犬血浆８－表氧－ＰＧＦ２α含量显著升高，结束照射后逐渐下降，但红细胞膜含量增加幅度更大，并于照射结束后第２天达高峰，然后开始下降；ＳＯＤ对其升高有显著的抑制作用。血浆与红细胞膜ＭＤＡ含量均无显著性改变。结论８－表氧－ＰＧＦ２α可作为观察放射损伤时脂质过氧化反应的一个新的较敏感的指标。
The levels of 8-epi-prostaglandin F2α (8-epi-PGF2α) in plasma and erythrocyte membrane during radiation injury in dogs were observed and compared with those of malondialdehyde (MDA) to explore the effect of 8-epi-PGF2α The value of peroxidation and the effect of SOD on it. Methods 18 adult mongrel dogs were irradiated with 60Coγ ray. The experiment was divided into low dose SOD group, high dose SOD group and control group with 6 mice in each group. The absorbed dose rate was 0.6Gy / d for 5 days (3.0Gy). The contents of 8-epi-PGF2α and MDA in plasma and erythrocyte membrane before and after irradiation were measured. Results During 60Co γ ray irradiation, the content of 8-epi-PGF2α in plasma was significantly increased and gradually decreased after irradiation. However, the content of erythrocyte membrane increased more and reached its peak on the second day after irradiation and then began to decline. SOD increased its significant inhibitory effect. Plasma and erythrocyte membrane MDA content had no significant change. Conclusion 8-epi-PGF2α can be used as a new sensitive index for observing lipid peroxidation during radiation injury.