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目的:探讨恒定功率踏车运动对稳定期COPD患者炎性细胞因子、肺功能及生活质量的影响。方法:55例稳定期COPD患者和60例正常人对照者进行恒定功率踏车运动,于运动前后采静脉血,使用双抗体夹心ABC-ELISA法测量血清IL-1、IL-6、和TNF-α浓度。试验组在运动前和12周运动后,分别测定肺功能指数、6分钟行走试验结果、Borg呼吸困难指数及相关生活质量指数。结果:试验组基础状态血清IL-1、IL-6、TNF-α水平显著高于对照组(P<0.05),与运动前相比,对照组运动后TNF-α水平无显著性改变(P>0.05),但IL-1、IL-6水平显著性升高(P<0.05);试验组IL-1、TNF-α水平运动后呈明显降低(P<0.05),而IL-6水平运动后并无显著意义的升高(P>0.05)。试验组患者在运动前及12周后6MWT、生活质量、呼吸困难评分、肺功能指标差异有统计学意义(P<0.05)。结论:持续12周踏车运动试验可有效控制稳定期COPD患者的临床症状,提高生活质量,并在一定程度上降低病人IL-1、TNF-α水平,但对降低IL-6水平的影响不大。
Objective: To investigate the effects of constant power treadmill exercise on inflammatory cytokines, lung function and quality of life in stable COPD patients. Methods: Fifty-five stable COPD patients and 60 normal controls were subjected to constant power treadmill exercise. Venous blood was collected before and after exercise. Serum IL-1, IL-6 and TNF-α levels were measured by double antibody sandwich ABC-ELISA. α concentration. The test group before and after 12 weeks of exercise were measured lung function index, 6-minute walk test results, Borg index of dyspnea and related quality of life index. Results: The levels of serum IL-1, IL-6 and TNF-α in the experimental group were significantly higher than those in the control group (P <0.05). Compared with those before exercise, the levels of TNF-α in the control group did not change significantly (P <0.05), but the levels of IL-1 and IL-6 were significantly increased (P <0.05). The levels of IL-1 and TNF- There was no significant increase (P> 0.05). The 6MWT, quality of life, dyspnea score and pulmonary function indexes in test group before and after 12 weeks were significantly different (P <0.05). CONCLUSION: The treadmill exercise test lasting 12 weeks can effectively control the clinical symptoms and improve the quality of life in patients with stable COPD, and to a certain extent reduce the level of IL-1 and TNF-α, but not the level of IL-6 Big.