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经鼻给予高效LH-RH类似物能诱发溶黄体并调节月经发生的时间。已知,正常妇女在LH峰后6～9天给予LH-RH后溶黄体的敏感性较高。本文报告正常妇女在黄体期中期一次鼻内给予大剂量[D-丝(叔丁基)~6-去甘酰胺~(10)]LH-RH乙基酰胺(Buserelin)后的垂体敏感性与黄体反应。方法:24个年龄20～40岁的志愿者参加本工作。在研究开始前至少6个月未服避孕丸或其它任何激素类药物,并至少作二个月的基温测定。她们的月经周期均规则(26～32天),无内分泌或妇科疾病。志愿者是在无妊娠危险的妇女中征募的。本工作至少包括4个月经周期,即二个治疗前
Nasal administration of high-potency LH-RH analogues can induce luteal phase and regulate menstrual cycle time. It is known that normal women have a higher sensitivity to solution of LH after RH 6 to 9 days after LH peak. This article reports the normal pituitary sensitivity of normal women after intranasal administration of a large dose of [D- (t-butyl) ~ 6-deganamide ~ (10)] LH-RH ethylamide (Buserelin) reaction. Methods: Twenty-four volunteers aged 20-40 participated in the work. No contraceptive pills or any other hormonal medication is taken for at least 6 months prior to the start of the study and a minimum of two months of baseline temperature determination are made. Their menstrual cycle rules (26 to 32 days), no endocrine or gynecological diseases. Volunteers are recruited in women without pregnancy risk. This work includes at least 4 menstrual cycles, that is, two before treatment