Ras基因最初是在和Kirston和Hayvey大鼠肉瘤中首先发现的 ,转导了ras基因的NIH 3T3细胞能发生恶性转化 ,从而确定了其癌基因的地位。进一步研究发现多数人类肿瘤中均有ras基因的突变激活 ,其中最常见于胰腺癌、结肠癌和肺癌[1] 。Ras基因家族由K ras、H ras、N ras三个密切相关 The Ras gene was first identified in Kirston and Hayvey rat sarcomas and NIH 3T3 cells transduced with the ras gene were malignantly transformed to confirm their oncogenes status. Further study found that most human tumors have ras gene mutations are activated, the most common in pancreatic cancer, colon cancer and lung cancer [1]. Ras gene family by K ras, H ras, N ras three are closely related