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感染性休克至今仍是中毒性痢疾、暴发型流脑、中毒性肺炎、败血症及化脓性胆道疾患等感染性疾病最重要的死亡原因之一。近年国外报道,其病死率仍高达40～70％。国内自50年代末期钱潮首先指出中毒性痢疾全身小血管痉挛系死亡的主要原因,创用阿托品治疗取得疗效以来,许多作者在茛菪类药物治疗和对微循环障碍在感染性休克发病机理中的作用进行了深入系统的研究,并已获得了令人鼓舞的进展。据统计,我国感染性休克病死率已自60年代的25～50％下降到13.4～11.2％。现就近年茛菪类药物治疗感染性休克的某些进展作一简要综述,以供参考。
Septic shock is still one of the most important causes of death in infectious diseases such as toxic dysentery, fulminant meningitis, toxic pneumonia, sepsis and purulent biliary disorders. In recent years, foreign reports, the case fatality rate is still as high as 40 to 70%. Since the end of 1950s, Qian Chao first pointed out the main reason for the death of systemic small vasospasm in toxic dysentery. Since the creation of atropine to treat the curative effect, many authors have been studying the mechanisms of anisodamine treatment and microcirculation in the pathogenesis of septic shock Conducted an in-depth and systematic study and have made encouraging progress. According to statistics, the mortality rate of septic shock in our country has dropped from 25% -50% in the 1960s to 13.4% to 11.2%. In recent years, the progress of septic drugs in the treatment of septic shock for a brief review, for reference.